Isoniazid, The Frontline of Resistance in Mycobacterium tuberculosis

Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates

The molecular basis of isoniazid resistance in Mycobacterium tuberculosis.

Isoniazid, the hydrazide of isonicotinic acid, was synthesized for the first time in 1912 by two Czech scientists, but its powerful antituberculous activity was detected only in 1951, and the discovery of isoniazid was a milestone in the chemotherapy of tuberculosis. Its activity is excellent against species of the Mycobacterium tuberculosis complex (M. tuberculosis, Mycobacterium bovis, Mycoba...

A STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS

Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...

In silico Analysis of Isoniazid Resistance in Mycobacterium tuberculosis

Altered drug binding may be an important factor in isoniazid (INH) resistance, rather than major changes in the enzyme’s activity as a catalase or peroxidase (KatG). The identification of structural or functional defects in the mutant KatGs responsible for INH resistance remains as an area to be explored. In this connection, the differences in the binding affinity between wild-type (WT) and mut...

Simultaneous ethambutol & isoniazid resistance in clinical isolates of Mycobacterium tuberculosis.

BACKGROUND & OBJECTIVE There is a need to understand the nature of drug resistance patterns and predictors of emergence of drug resistance in Mycobacterium tuberculosis. There could be common factors/mechanisms for resistance to the drugs, isoniazid and ethambutol, both acting on cell wall. The present study was conducted to analyze the antimycobacterial susceptibility patterns of M. tuberculos...